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Chronic Gastric Diseases

Definition:  Chronic  Vomiting
-  Past  surgical  history
- Acute vomiting that fails to respond to
appropriate  symptomatic  therapyApproach  to  Vomiting:
- Untreated vomiting that persists longer-  Primary  GI
than  two  weeks
-  Gastric
-  Consistent
-  Small  intestinal
-  Intermittent  or  episodic
-  Colonic
Approach  to  Vomiting
-  Secondary  GI
-  Primary  GI
-  Systemic  illness that affects GI function
-  Gastric
Chronic  Vomiting:
-  Small  intestinal
Diagnostic  Steps
-  Colonic
-  CBC,  biochemistry  profile,  UA
-  Secondary  GI
-  Fecal
-  Systemic  illness that affects GI function
-  Survey  abdominal  radiographs
Secondary  GI  Causes  of  Vomiting
-  Cats:
SYSTEM
-  T4  if  over  6  yrs,  FeLV,  FIV
-  Kidneys
-  occult  heartworm  test
-  Liver
-  Elimination  diet
-  Exocrine  pancreas
-  Endoscopy
-  Endocrine  pancreas
-  Abdominal  ultrasound
-  Adrenals
-  Barium  series
-  Peritoneum
-  Laparatomy
-  CNS
Approach  to  Chronic  Vomiting
-  Thyroid
CBC,  biochemistry  profile,  UA,  fecal
-  Uterus
Survey  abdominal  radiographs
-  Systemic  infection
Cats: T4 if over 6 yrs, FeLV, FIV (occult
Disease:heartworm  test)
-  Renal  failureMild  Signs:
-  Hepatic  disease-  Elimination  diet
-  PancreatitisSignificant  Clinical  Signs:
-  DKA-  Endoscopy
-  Addison's-  Abdominal  ultrasound
-  Peritonitis-  Barium  series
-  Cerebral  or  vestibular  disease-  Laparotomy
-  HyperthyroidismOverview:
-  PyometraGastric  Causes  of  Chronic  Vomiting
-  Sepsis-  Chronic  gastritis
Overview:-  Lymphocytic/plasmacytic
Gastric  Causes  of  Chronic  Vomiting-  Eosinophilic
-  Chronic  gastritis-  Associated  with  GHLOs
-  Lymphocytic/plasmacytic-  Parasitic
-  Eosinophilic-  Reflux  gastritis
-  Associated  with  GHLOs-  Gastric  foreign  body
-  Parasitic-  Gastric  ulceration
-  Reflux  gastritis-  Gastric  motility  disorders
-  Gastric  foreign  body-  Gastric  neoplasia
-  Gastric  ulcerationChronic  Gastritis
-  Gastric  motility  disordersClassified by etiology, breed, and/or
histopathology
-  Gastric  neoplasia
Types  of  Chronic  Gastritis
Overview:
- Lymphocytic/plasmacytic gastritis (Chronic
Intestinal  Causes  of  Chronic  Vomitingnon-specific  gastritis,  IBD)
-  Inflammatory  bowel  disease  (IBD)-  Eosinophilic  gastritis
-  Intestinal  neoplasia-  Granulomatous  gastritis
-  Duodenal  ulcers-  Atrophic  gastritis
-  Fungal  enteritis-  Gastritis  associated  with  GHLOs
-  Chronic  intussusception-  Parasitic  gastritis
-  Foreign  bodies-  Reflux  gastritis
-  ColitisEtiopathogenesis of Chronic Lymphocytic
Plasmacytic  Gastritis
Chronic  Vomiting:  History
-  Non-specific  reaction  to  many  insults
-  Characterize  vomiting
- Either wall defects allow antigen
-  Onsetabsorption from stomach stimulating immune
response OR breakdown in immune tolerance
-  Duration(auto-immune  gastritis)
-  Frequency- Mucosal damage allows back-diffusion of
acid
-  Progression
- Gastric inflammation compromises motility,
-  Relationship  to  eatingsecretions and plasma proteins lost into
lumen
- Specific features (blood, foreign material,
undigested  food,  projectile,  etc.)Chronic Lymphocytic/Plasmacytic Gastritis:
Clinical  Features
- Response to changes in diet or feeding
schedule,  medication,  other  changes- Persistent intermittent vomiting
exacerbated  by  eating
Associated  clinical  signs-
- Diarrhea occurs if animal has concurrent
-  Appetite  changesIBD  of  intestines
-  Weight  loss- PE, CBC, chemistries, UA, fecal, and survey
radiographs  -  typically  NAF
-  Diarrhea
Chronic Lymphocytic/Plasmacytic Gastritis:
-  Changes  in  attitude  (lethargy)Diagnosis
-  PU/PD- Obtain endoscopic biopsies or
full-thickness  biopsies  by  laparotomy
-  Cough,  tachypnea,  dyspnea
- Infiltration of the gastric mucosa
-  Otherpredominantly with lymphocytes and plasma
cells
-  Potential  exposures  prior  to  onset:
- Mucosa may be normal thickness (simple
-  Medicationsgastritis), increased (hypertrophic), or
decreased  (atrophic)
-  Plants
Note: Mucosal hypertrophy can cause outflow
-  Toxinsobstruction
-  GarbageChronic Lymphocytic/Plasmacytic Gastritis:
Treatment
-  Potential  foreign  bodies
PRIMARY  THERAPY
-  Other  sick  animals
-  +/-  NPO  or  "no  food"  for  24-48 hours
-  Dietary  history
-  Multiple  small  daily  meals
-  Deworming  history
-  Easily  digested  diet  (i/d)
-  Vaccination  status
- Novel protein diet (e.g.
-  Past  medical  history



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